1. Short-term stressors that initiate cases of multisystem illnesses act by raising nitric oxide and/or other cycle elements. 2. Initiation is converted into a chronic illness through the action of vicious cycle mechanisms, through which chronic elevation of peroxynitrite and other cycle elements is produced and maintained. 3. Symptoms and signs of these illnesses are generated by elevated levels of nitric oxide and/or other important consequences of the proposed mechanism, i.e. elevated levels of peroxynitrite or inflammatory cytokines, oxidative stress, elevated NMDA and TRPV1 receptor activity, ATP and BH4 depletion and others. 4. Because the compounds involved, nitric oxide, superoxide and peroxynitrite have quite limited diffusion distances in biological tissues and because the mechanisms involved in the cycle act at the level of individual cells, the fundamental mechanisms are local. The consequences of this primarily local mechanism show up in the multisystem illnesses through the stunning variations one sees in symptoms and signs from one patient to another. -- Source: Martin Pall, The Tenth ParadigmDr. Pall came up with a testable theory to explain how the body could become sensitized to a wide variety of foods, chemicals and allergens. There is some proof that his theories are valid, at least in part. However, the treatment regiment prescribed by his theory did not alter the progression of my medical condition. In retrospect, simple interruption of the NO/ONOO- cycle through the use of antioxidants and mitrodchondrial support supplements was not sufficient to cure my severe sensitivities. Therefore, when I learned about 'amygdala retraining' as a possible method to cure chronic fatigue syndrome, I recognized that the same methods used to successfully treat chronic fatigue syndrome might also apply to chemical and food sensitivities. I was one of the first guinea pigs who tried using these amygdala retraining techniques on my chemical and food sensitivities. According to Ashok Gupta, the amygdala mediates the brain's response to potentially dangerous external stimuli:
"The amygdala is responsible for detecting threats to the body, and initiating appropriate responses to mitigate those threats. The insula modulates sensory experiences and information about the physiological state of the body. During a particularly stressful period in someone’s life, the amygdala is on high alert responding to emotional and physical threats. If the level of alert of the amygdala is particularly high, and the person is exposed to a toxin at the same time, a conditioned trauma can occur in the amygdala in association with the insula. This conditioning occurs because when the amygdala is on high alert, it is very prone to learning new fears and sensitivities. Even if the original toxin did not present a threat to life, the amygdala will “err on the side of caution” in it hyper-anxious state, in order to protect the body. From then on, any exposure to the original chemical, or any chemical which holds a vague resemblance to the original trigger, will initiate an over-stimulation of the sympathetic nervous system by the amygdala and hypothalamus, as well as specific reactions to mitigate the threat of the toxin. This conditioning means that the whole circuit becomes hard wired, and chronic. The brain continually over-responds to any chemical or odour which reminds it of the original sensitising chemical. On top of that, the brain may generalize even further and begin to react to other very different chemicals, if it begins to get signals from other parts of the brain that this is an appropriate response. In summary, MCS is a conditioned response of the brain to a chemical it thinks is dangerous. It is a mistake that the brain makes and creates an over-protective response." -- Source: Ashok Gupta, Gupta Programme.I was a successful guinea pig, meaning that I experienced significant progress in reversing and eliminating my sensitivities while using Gupta's program. However, Gupta's amygdala retraining techniques are very difficult to implement:
The best analogy I've come up with to explain the difficulty of implementing this program is to imagine that you've had a stroke, and you've lost the use of your right arm. You receive a DVD set in the mail that explains how to rewire your brain, how to 'route around' the damaged portions of your brain, so that you can use your right arm again. Now -- go implement this program on your own, without the benefit of a physical therapist or doctor. And let us know when your arm is working again! :) This was, without a doubt, the most difficult thing I will ever have to do in my life. But I did it! My recovery is about 99% complete. I did this by spending around 6,000-8,000 hours neurohacking my way to health, over the course of 3 years. I literally have my life back, and I'm healthier now than I've been in over 15 years. When I write about neurohacking on this blog, and when I write about how you can use these same techniques to create change in yourself, it comes from a lot of practical experience. The changes in my life have been miraculous and transformative. These days, I'm focused on health issues like 'joy' and 'body composition'. It's a much, much, much better place to be! :)
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Source: Novel Disease Paradigm Produces Explanations for a Whole Group of Illnesses, Martin Pall, http://www.thetenthparadigm.org/index.html Source: The Gupta Programme, Ashok Gupta, http://www.guptaprogramme.com/mcs-multiple-chemical-sensitivity-treatment/
Written on 2013/10/02